Unlike other medications, Mounjaro has a long clearance time. It stays in your body for a duration of about 25 to 30 days after your last injection.
If you are using Mounjaro to support weight loss and diabetes, then it is important to be aware of how long Mounjaro remains active in your system. This article aims to explain the half-life of Mounjaro, its approximate clearance time according to dosage, and the potential side effects that may occur after stopping the medication.
How Long Does Mounjaro Last In Your System?
The time it takes for a medicine to be fully cleared from your body depends on its half-life. The half-life of a medicine is a pharmacokinetic parameter that indicates the amount the time it takes for a drug to be reduced to half in the body.
The half-life of Mounjaro is generally five days. This means that after the five days of injection, the amount of trizapatide in your body will be reduced to half of its initial amount.
Also Read: What is Mounjaro maintenance dose?
So, the effect of Mounjaro starts to wear off after a week of its injection. But for the medicine to be completely cleared from your system, it might take around 25 to 30 days.
How Mounjaro Affects The Body?
Mounjaro (trizepatide) is an injectable drug that helps to treat type 2 diabetes. It works by activating GLP-1 and GIP hormones.
With each weekly injection, these hormones help in controlling the appetite, managing blood sugar levels, and promoting gradual weight loss.
Mounjaro Clearance Time According To Dosage
The clearance time of a medicine can vary depending on the amount of dosage. It means that if a person takes a high dose of Mounjaro, then its clearance time might extend beyond 30 days.
|
Dose of Mounjaro |
Approximate Clearance Time |
|
2.5 mg |
25 days |
|
5.0 mg |
28 to 30 days |
| 7.5 mg |
30+ days |
Factors Affecting Clearance Time
Apart from the amount of dosage, there are many other key factors that can affect the duration of Mounjaro in your body.
Firstly, a person’s metabolism rate can affect the amount of time Mounjaro stays in the system. People with fast metabolism can get Mounjaro out of their bodies quickly, as compared to people with a slow metabolism rate.
Secondly, the health of the kidneys and liver in a person’s body can also affect the clearance time of Mounjaro.
Thirdly, a person who has been using Mounjaro for a long time might also face a delay in its complete clearance from their body.
Also Read: Does Mounjaro Cause Hair Loss?
How to Remove Mounjaro From Your Body Quickly?
It is better to let the medicine leave your body naturally. However, you can speed up the process by staying hydrated, working out, and eating a healthy, balanced diet. The healthier your body is, the faster it’ll work to remove the effects of Mounjaro or any other drug from your system without leading to any harmful side effects.
Side Effects After Stopping Mounjaro
If you have been taking Mounjaro for weight loss or to treat diabetes, then stopping the medication may come with the following side effects:
- Weight Gain: It’s most likely that your body will gain some weight after stopping the use of Mounjaro. A study showcased that people suffering from obesity regained 14% of their body weight after they stopped taking Mounjaro.
- Increase in Appetite: Users have reported an increase in appetite when they stopped using Mounjaro. Since the medicine activated the specific hormones that controlled appetite, stopping its use can lead to a person feeling hungrier even after meals.
- Digestive Issues: Many users reported experiencing digestive discomfort after discontinuing the use of Mounjaro. Common digestive issues included vomiting, bloating, gas, nausea, and diarrhea.
- Unstable Blood Sugar Levels: Diabetic users may experience a spike in blood sugar levels upon discontinuing Mounjaro. Mounjaro regulates insulin in the body, and its absence could lead to a recurrence of diabetic issues for some people.
Hence, a person should seek medical guidance from a professional before taking or stopping the use of any medicine.
Frequently Asked Questions
Does the effect of Mounjaro decrease toward the end of the week?
Mounjaro is a once-weekly injection and levels gradually decline before the next dose, which some falsely perceive as “completely wearing off.”
How to get Mounjaro out of your system faster?
You cannot safely speed elimination; it leaves the body gradually based on its natural half-life.
Can you stop Mounjaro cold turkey?
Yes, Mounjaro can be stopped without tapering, but appetite and blood sugar may rebound, so medical guidance is advised.